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Diseases

The data suggests that, despite common inflammatory mechanisms, people with cystic fibrosis may present a form of COVID-19 that is often less severe than expected, possibly thanks to cellular characteristics of CF and the potential protective effect of CFTR modulators.

This study shows that delayed access to Trikafta would lead to more serious lung diseases, more exacerbations, more deaths, and significantly lower life expectancy in people with cystic fibrosis compared to early access.

The “crude” form of cystic fibrosis is a mild form, often diagnosed in adulthood, associated with partially functional CFTR mutations, with little or no digestive impairment and a respiratory evolution that is generally slow and favorable.

Pulmonary hypertension is a possible complication of advanced cystic fibrosis, caused by a chronic lack of oxygen, which can lead to right heart failure, while it remains rare after a lung transplant unless there is a severe respiratory problem.

Colds and flu are more common in winter because viruses circulate more in closed environments, are easily transmitted between people and can cause complications in people with cystic fibrosis.

New emerging pathogens in cystic fibrosis (MRSA, Stenotrophomonas maltophilia, and Achromobacter xylosoxidans) are becoming more and more frequent, but their exact impact on lung function and survival is still partially unclear.